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Effect of intravenous magnesium sulfate on mortality in patients with severe acute asthma
Author(s) -
Hirashima Junko,
Yamana Hayato,
Matsui Hiroki,
Fushimi Kiyohide,
Yasunaga Hideo
Publication year - 2016
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12733
Subject(s) - medicine , asthma , mechanical ventilation , propensity score matching , magnesium , anesthesia , randomized controlled trial , acute severe asthma , surgery , respiratory disease , lung , materials science , metallurgy
Background and objective Intravenous magnesium sulfate is used as adjunctive therapy for severe asthma exacerbations. However, previous randomized controlled trials of the administration of intravenous magnesium sulfate for asthma exacerbations have shown mixed results, and no study has evaluated its effect on mortality in patients with life‐threatening asthma. The objective of this study was to investigate the association between intravenous magnesium sulfate administration and mortality in patients with severe asthma. Methods Patients with severe asthma requiring intravenous corticosteroids and oxygenation were selected using the J apanese D iagnosis P rocedure C ombination inpatient database. One‐to‐one propensity score matching was performed between patients having received or not intravenous magnesium sulfate. Primary outcomes were 7‐, 14‐ and 28‐day mortalities. Secondary outcomes were total dose of intravenous corticosteroids during hospitalization, duration of mechanical ventilation and length of stay. Results Among 14 122 eligible patients, 619 received intravenous magnesium sulfate. Propensity score matching created a matched cohort of 599 pairs with and without intravenous magnesium sulfate. There were no significant differences between patients with and without intravenous magnesium sulfate in terms of 28‐day mortality (1.3% vs 1.8%, P = 0.488), median total dose of intravenous corticosteroids (2400 mg vs 2400 mg, P = 0.580), median duration of mechanical ventilation (1 day vs 1 day, P = 0.118) and median length of stay (16 days vs 13 days, P = 0.640). Conclusion This study found no significant benefit of intravenous magnesium sulfate use in terms of mortality in patients with severe acute asthma.