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Breathing pattern and breathlessness in idiopathic pulmonary fibrosis: An observational study
Author(s) -
Olukogbon Kasope L.,
Thomas Paul,
Colasanti Ricardo,
HopeGill Ben,
Williams Edgar Mark
Publication year - 2016
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12686
Subject(s) - medicine , idiopathic pulmonary fibrosis , vital capacity , pulmonary function testing , cohort , ventilation (architecture) , interstitial lung disease , tidal volume , cardiology , diffusing capacity , lung volumes , spirometry , lung , respiratory system , lung function , mechanical engineering , asthma , engineering
Background and objective Idiopathic pulmonary fibrosis ( IPF ) is characterized by progressive decline in lung function and increasing dyspnoea. The aim of this study was to investigate the relationship among IPF , pulmonary function, resting tidal breathing patterns and level of breathlessness. Methods Thirty‐one participants with IPF and 17 matched healthy controls underwent lung function testing, followed by a 2‐min period of resting tidal breathing. The IPF cohort was stratified according to disease severity, based on their forced vital capacity and diffusion capacity for carbon monoxide. Results In comparison to the healthy controls, the IPF cohort showed a higher tidal volume, V T , of 0.22 L ( P = 0.026) and a raised minute ventilation in the severest IPF group, while no differences in the timing of inspiration or expiration were observed. In the IPF cohort, the ratio of V T to forced vital capacity was around 15% higher. These changes corresponded with an increase in the self‐reported sensation of breathlessness. Conclusion Those with IPF increased their depth of breathing with worsening disease severity, with IPF ‐induced changes in pulmonary function and breathlessness associated with an altered tidal breathing pattern.