Role of a functional polymorphism in the   F2R   gene promoter in sarcoidosis | Zendy

Platé Manuela | Zendy; Lawson Phillippa J. | Zendy; Hill Michael R. | Zendy; Marshall Richard P. | Zendy; Booth Helen L. | Zendy; Kumari Meena | Zendy; Laurent Geoffrey J. | Zendy; Hurst John R. | Zendy; Chambers Rachel C. | Zendy

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Role of a functional polymorphism in the F2R gene promoter in sarcoidosis

Author(s) -

Platé Manuela,

Lawson Phillippa J.,

Hill Michael R.,

Marshall Richard P.,

Booth Helen L.,

Kumari Meena,

Laurent Geoffrey J.,

Hurst John R.,

Chambers Rachel C.

Publication year - 2015

Publication title -

respirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.857

H-Index - 85

eISSN - 1440-1843

pISSN - 1323-7799

DOI - 10.1111/resp.12608

Subject(s) - sarcoidosis , medicine , inflammation , single nucleotide polymorphism , allele , gene , immunology , disease , pathology , genotype , genetics , biology

Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by increased inflammation, and results from gene–environment interactions. Proteinase‐activated receptor‐1 mediates the interplay between coagulation and inflammation. The rs2227744G > A promoter single nucleotide polymorphism has been linked to inflammation, cardiovascular disease and chronic obstructive pulmonary disease exacerbations. Using a case‐control study (184 cases with sarcoidosis and 368 controls), we show that the rs2227744A allele significantly associates with protection from sarcoidosis ( P = 0.003, OR = 0.68 (0.52–0.88)).

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