Premium
Non‐anaemic iron deficiency impairs response to pulmonary rehabilitation in COPD
Author(s) -
BarberanGarcia Anael,
Rodríguez Diego Agustín,
Blanco Isabel,
Gea Joaquim,
Torralba Yolanda,
ArbillagaEtxarri Ane,
Barberà Joan Albert,
Vilaró Jordi,
Roca Josep,
OrozcoLevi Mauricio
Publication year - 2015
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12591
Subject(s) - medicine , copd , pulmonary rehabilitation , aerobic exercise , confounding , pulmonary disease , vo2 max , physical therapy , prospective cohort study , gastroenterology , heart rate , blood pressure
Background and objective Non‐anaemic iron deficiency ( NAID ) might alter the oxygen pathway in health and disease. The current study aims at assessing the impact of NAID on aerobic capacity in patients with chronic obstructive pulmonary disease ( COPD ). Methods A prospective sample of 70 non‐anaemic COPD patients candidate to participate in an 8‐week pulmonary rehabilitation ( PR ) programme was studied. Incremental cycling exercise to peak oxygen uptake ( V'O 2peak ) and constant work‐rate exercise at 80% V'O 2peak to exhaustion were assessed pre‐ and post‐ PR . Training‐induced increase of endurance time ( ET ) ≥33%, which represented the minimal clinically important difference, classified patients as responders to exercise training. Results The prevalence of NAID was 48% ( n = 34) showing no relationship with the G lobal I nitiative for C hronic O bstructive L ung D isease stages ( P = 0.209). Patients with NAID showed lower pre‐training ET ( P = 0.033) and V'O 2peak ( P = 0.007) than normal iron status ( NIS ) patients after adjustment for potential covariates. Significant training‐induced physiological changes were seen in the NIS group (Δ V'O 2peak 68(132) mL/min; P = 0.009), but not in the NAID group (Δ V'O 2peak 26 (126) mL/min; P = 0.269). The NAID group showed lower percentage of responders to training (56%) than the NIS group (78%) ( P = 0.041). Conclusions COPD patients with NAID showed lower pre‐training aerobic capacity and reduced training‐induced response than NIS patients after adjusting for potential confounding variables.