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Aetiology and clinical characteristics of patients with bronchiectasis in a C hinese H an population: A prospective study
Author(s) -
Qi Qian,
Wang Wen,
Li Tao,
Zhang Yan,
Li Yu
Publication year - 2015
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12574
Subject(s) - bronchiectasis , medicine , primary ciliary dyskinesia , etiology , allergic bronchopulmonary aspergillosis , population , sputum , tuberculosis , prospective cohort study , immunology , lung , pathology , immunoglobulin e , antibody , environmental health
Background and objective Bronchiectasis is a chronic respiratory disease with diverse causes that may differ in clinical features and thus treatment options. However, few large‐scale studies on the aetiology of bronchiectasis are currently available. This study aims to determine aetiology and clinical features of bronchiectasis in a C hinese H an population. Methods This prospective study enrolled adult patients diagnosed with bronchiectasis as confirmed by high‐resolution computed tomography at five general hospitals in Shandong from J anuary 2010 to A ugust 2014. Causes of bronchiectasis were sought by analysis of clinical history and auxiliary examinations (including serum immunoglobulin determination, saccharin test, Aspergillus skin prick test, autoantibody detection and electronic bronchoscopy). Results A total of 476 adult patients with bronchiectasis were included, and all patients were of C hinese H an ethnicity. Idiopathic (66.0%) was the most common cause, followed by post‐tuberculosis (16.0%). Other uncommon causes included post‐infective (3.8%), immunodeficiency (3.8%), allergic bronchopulmonary aspergillosis (4.0%), rheumatic diseases (4.4%) and primary ciliary dyskinesia (0.9%). Patients with post‐tuberculosis bronchiectasis had a higher frequency of upper lobe involvement ( P < 0.05). Cylindrical bronchiectasis was the most common type of all causes, with varicose bronchiectasis occurring more frequently in post‐tuberculosis bronchiectasis and allergic bronchopulmonary aspergillosis ( P < 0.05). However, patients with different causes did not differ in lung function and sputum isolation rate of P seudomonas aeruginosa ( P > 0.05). Conclusions In a C hinese H an population in Shandong, idiopathic bronchiectasis is the most common form of bronchiectasis followed by post‐tuberculosis bronchiectasis. Patients with different causes differ in distribution and pattern of bronchiectasis on computed tomography.