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Increases in peripheral SIRT 1: A new biological characteristic of asthma
Author(s) -
Wang Yajun,
Li Dongming,
Ma Guoda,
Li Wen,
Wu Jun,
Lai Tianwen,
Huang Dan,
Zhao Xuanna,
Lv Quanchao,
Chen Min,
Wu Bin
Publication year - 2015
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12558
Subject(s) - asthma , medicine , ovalbumin , sirtuin 1 , immunoglobulin e , eosinophil , immunology , allergy , lung , endocrinology , antibody , immune system , downregulation and upregulation , biology , biochemistry , gene
Background and objective Silent information regulator 1 ( SIRT 1) is a class III histone deacetylase that exerts both anti‐inflammatory and anti‐aging effects. However, no data are available regarding SIRT 1 expression in patients with asthma. Here, we studied SIRT1 levels in the serum of patients with asthma and analysed the distribution of SIRT 1 in both the serum and the lungs in an asthmatic mouse model to determine its clinical significance. Methods Serum SIRT 1 levels, total immunoglobulin E ( IgE ) levels and peripheral blood eosinophil percentages as well as pulmonary function were quantified in 97 patients with asthma and 118 healthy volunteers. BALB /c mice were sensitized and challenged using ovalbumin ( OVA ) to produce the asthmatic model, and SIRT 1 levels in both the serum and the lung tissues were subsequently measured. Results The serum SIRT 1 levels were significantly elevated in the patients with asthma compared with the controls. Serum SIRT 1 levels positively correlated with total IgE levels and negatively correlated with pulmonary function. In the OVA ‐sensitized and challenged mice, an increased serum SIRT 1 level was confirmed, whereas decreased SIRT 1 expression was observed in the lung tissues. Conclusions These data indicate that lung SIRT 1 expression decreased while serum SIRT 1 increased in the setting of asthma. Serum SIRT 1 levels correlate positively with both IgE levels and negatively with pulmonary function, suggesting that increased peripheral SIRT 1 levels represent a new biological characteristic of asthma. Increased serum SIRT 1 may be an auxiliary index for the diagnosis of asthma and elevating lung SIRT 1 levels may be a new strategy for asthma therapy.