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The relationship between fat‐free mass index and pulmonary hyperinflation in COPD patients
Author(s) -
Silveira Leonardo,
Teixeira Paulo José Zimermann,
Costa Cassia C.,
Souza Rafael M.,
Merola Pietro Krauspenhar,
Colombo Caroline,
Marques Renata D.,
Berton Danilo C.
Publication year - 2014
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12406
Subject(s) - medicine , fat free mass , copd , body mass index , hyperinflation , pulmonary disease , index (typography) , fat mass , economics , monetary policy , monetary economics , world wide web , computer science
Background and objective Reduced fat‐free mass ( FFM ), a common finding in chronic obstructive pulmonary disease ( COPD ), may indirectly impact peak exercise capacity through a greater level of pulmonary hyperinflation. We aimed to investigate if FFM index ( FFM /squared height) impacts exercise induced dynamic hyperinflation in COPD patients. Methods Fifty‐four patients with moderate‐to‐very severe COPD performed a symptom limited incremental cardiopulmonary exercise tests with serial measurements of inspiratory capacity ( IC ). FFM was measured by whole‐body bioelectrical impedance. Results Patients were 66.7 ± 7.7 years old with mean forced expiratory volume in 1 s ( FEV 1 ) of 1.08 ± 0.41 L (42 ± 15% of predicted). Peak exercise IC was significantly ( P < 0.05) correlated with IC at rest ( r = 0.78), FEV 1 ( r = 0.66), FVC ( r = 0.59), FFM ( r = 0.38) and FFM index ( r = 0.29). However, only FEV 1 and rest IC predict peak IC ( r = 0.86; P < 0.01) in a multivariate linear regression analysis. Conclusions FFM index was weakly associated with peak exercise IC in COPD patients. However, it ceased to be an independent predictor when corrected for expiratory airflow limitation ( FEV 1 ) and lung hyperinflation at rest (rest IC ).