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Polymorphisms in a disintegrin and metalloprotease 33 gene and the risk of chronic obstructive pulmonary disease: A meta‐analysis
Author(s) -
Zhang Rui,
Li He,
Zhao Haiming,
Chen Wangyue,
Cheng Deyun
Publication year - 2014
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12235
Subject(s) - copd , meta analysis , odds ratio , medicine , subgroup analysis , case control study , polymorphism (computer science) , confidence interval , genetics , bioinformatics , genotype , gene , biology
A number of polymorphisms in a disintegrin and metalloprotease 33 ( ADAM33 ) gene have been implicated in susceptibility to chronic obstructive pulmonary disease ( COPD ). However, results to date have been inconclusive. We conducted meta‐analyses to investigate the associations between multiple polymorphisms in ADAM33 gene and COPD susceptibility. P ubMed, E mbase and C hinese databases ( W anfang and C hina National Knowledge Infrastructure) were searched for eligible case‐control studies. We extracted data and used meta‐analysis to calculate pooled odds ratios with 95% confidence intervals to evaluate the strength of associations. Twelve studies containing six ADAM33 polymorphisms ( F +1, S1 , S2 , T1 , V4 and Q ‐1) were identified, which involved 2630 cases and 4376 controls. ADAM33 S1 polymorphism showed stable and significant associations with COPD risks among the Chinese and smoking populations, and Q ‐1 polymorphism showed stable and significant associations with COPD risks among the overall populations. In subgroup analyses, T1 and Q ‐1 polymorphisms were significantly associated with COPD risks among the C hinese and smoking populations, and among the C hinese, Caucasians and smoking populations, respectively. However, none of the significant results was stable in sensitivity analyses. With respect to F +1, S2 or V4 polymorphism, there was no evidence of any significant association with COPD risks in either the overall or the subgroup analysis. The results of this meta‐analysis indicate that ADAM33 S1 polymorphism is a risk factor for COPD among the C hinese and smoking populations, and that Q ‐1 polymorphism is a risk factor for COPD among the overall populations.