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Mesenteric fat thickness is associated with increased risk of obstructive sleep apnoea
Author(s) -
Liu Kin Hung,
Chu Winnie C.W.,
To Kin Wang,
Ko Fanny W.S.,
Ng Susanna S.S.,
Ngai Jenny C.L.,
Chan Jeff Wai Sang,
Ahuja Anil T.,
Hui David S.C.
Publication year - 2014
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12164
Subject(s) - medicine , body mass index , adipose tissue , odds ratio , polysomnography , gastroenterology , surgery , apnea
Background and objective Mesenteric fat is a type of intraperitoneal adipose tissue draining into portal circulation. The objective of this study was to investigate the relationships between mesenteric fat thickness and obstructive sleep apnoea ( OSA ) in patients with suspected OSA . Methods One hundred forty‐nine subjects (men: 114; women: 35) with suspected OSA underwent ultrasound examinations of mesenteric, preperitoneal and subcutaneous fat thickness after overnight polysomnography. Body mass index ( BMI ) and neck circumference were recorded. Results The subjects with OSA ( n = 130, apnoea/hypopnoea index ( AHI ) >5/h) had greater neck circumference, higher BMI , and greater mesenteric and preperitoneal fat thickness than those without OSA ( n = 19, AHI ≤ 5/h). There was positive correlation of AHI with mesenteric (r = 0.43, P < 0.001) and preperitoneal fat thickness (r = 0.3, P < 0.001), whereas no significant association was observed between AHI and subcutaneous fat thickness (r = 0.09, P = 0.27). On multivariate logistic regression, after adjustments for gender, age, BMI , neck circumference, and preperitoneal and subcutaneous fat thickness, the mesenteric fat thickness had a positive association with the presence of moderate OSA and severe OSA , with odds ratios of 7.18 and 7.45 for every 1 cm increase in mesenteric fat thickness when AHI was defined as ≥15/h and AHI ≥ 30/h, respectively. Conclusions Mesenteric fat thickness is associated with increased risk of OSA , independent of other abdominal fat thickness, BMI and neck circumference. Sonographic measurement is potentially a useful tool for further evaluating the complex association of visceral fat, metabolic syndrome and OSA .