Premium
Comparison of performance status with peak oxygen consumption in operable patients with non‐small‐cell lung cancer
Author(s) -
Roman Michael A.,
Koelwyn Graeme J.,
Eves Neil D.,
Hornsby Whitney E.,
Watson Dorothy,
Herndon II James E.,
Kohman Leslie,
Loewen Gregory,
Jones Lee W.
Publication year - 2014
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12162
Subject(s) - medicine , cardiorespiratory fitness , lung cancer , performance status , vo2 max , oncology , cancer , physical therapy , heart rate , blood pressure
Background and objective In this era of increasing options for treatment of ‘surgical’ lung cancer patients, preoperative physiologic assessment of accurate patient selection is becoming more important. The variability in an objective measure of cardiorespiratory fitness (peak oxygen consumption ( VO 2peak )) across performance in operable non‐small‐cell lung cancer ( NSCLC ) patients enrolled in the C ancer and L eukemia G roup B trial was compared. Methods Using a cross‐sectional design, 392 NSCLC patients underwent an incremental cardiopulmonary cycling exercise test to symptom limitation with expired gas analysis to determine VO 2peak . Performance status ( PS ) was assessed using the E astern C ooperative O ncology G roup ( ECOG ) tool. Results There was a significant decrease in VO 2peak across increasing ECOG categories ( P < 0.0001). However, there was a large range in VO 2peak for any given ECOG category with overlap between categories ( ECOG 0: 5.0–31.5 m L /kg/min; ECOG 1: 4.3–24.8 m L /kg/min; ECOG 2: 8.9–21.9 m L /kg/min; ECOG 3; 3.3–11.7 m L /kg/min). Conclusions PS scoring systems do not provide a sensitive measure of functional status. Objective measures such as VO 2peak may be a useful in the clinical management of oncology patients.