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Elevated circulating cytotoxic T lymphocyte‐associated antigen‐4 levels are related to lung function and inflammation in chronic obstructive pulmonary disease
Author(s) -
Shen Yongchun,
Yang Ting,
Wang Tao,
Chen Lei,
Wen Fuqiang
Publication year - 2013
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12113
Subject(s) - medicine , copd , cytotoxic t cell , immunology , inflammation , immune system , antigen , ctla 4 , pulmonary disease , c reactive protein , lung , lymphocyte , t lymphocyte , t cell , in vitro , biology , biochemistry
Cytotoxic T lymphocyte‐associated antigen‐4 ( CTLA‐ 4) is involved in immune and inflammation regulation. The present study aimed to investigate the association between CTLA ‐4 and COPD . Data revealed that serum levels of CTLA ‐4 were elevated in COPD patients, inversely correlated with lung function and positively correlated with serum C ‐reactive protein levels in the COPD group. These findings suggest that CTLA ‐4 may play a role in COPD .