Elevated circulating cytotoxic T lymphocyte‐associated antigen‐4 levels are related to lung function and inflammation in chronic obstructive pulmonary disease | Zendy

Shen Yongchun | Zendy; Yang Ting | Zendy; Wang Tao | Zendy; Chen Lei | Zendy; Wen Fuqiang | Zendy

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Elevated circulating cytotoxic T lymphocyte‐associated antigen‐4 levels are related to lung function and inflammation in chronic obstructive pulmonary disease

Author(s) -

Shen Yongchun,

Yang Ting,

Wang Tao,

Chen Lei,

Wen Fuqiang

Publication year - 2013

Publication title -

respirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.857

H-Index - 85

eISSN - 1440-1843

pISSN - 1323-7799

DOI - 10.1111/resp.12113

Subject(s) - medicine , copd , cytotoxic t cell , immunology , inflammation , immune system , antigen , ctla 4 , pulmonary disease , c reactive protein , lung , lymphocyte , t lymphocyte , t cell , in vitro , biology , biochemistry

Cytotoxic T lymphocyte‐associated antigen‐4 ( CTLA‐ 4) is involved in immune and inflammation regulation. The present study aimed to investigate the association between CTLA ‐4 and COPD . Data revealed that serum levels of CTLA ‐4 were elevated in COPD patients, inversely correlated with lung function and positively correlated with serum C ‐reactive protein levels in the COPD group. These findings suggest that CTLA ‐4 may play a role in COPD .

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