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Short‐acting anticholinergic bronchodilation does not increase cardiovascular events in smokers with mild to moderate pulmonary obstruction
Author(s) -
Jong Emmy,
Dijk Wouter D.,
Heijdra Yvonne,
Lenders Jacques W. M.,
Weel Chris,
Akkermans Reinier,
Schermer Tjard R. J.
Publication year - 2013
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12040
Subject(s) - medicine , bronchodilation , copd , anticholinergic , cardiology , hazard ratio , comorbidity , anesthesia , bronchodilator , asthma , confidence interval
Background and objective We hypothesized that bronchodilation in patients with chronic obstructive pulmonary disease ( COPD ) increases the smoke‐related risk to develop cardiovascular disease, and aimed to study the effect of short‐acting anticholinergic bronchodilation and smoking on cardiovascular events. Methods We performed a secondary analysis on data from the L ung H ealth S tudy, a large randomized clinical trial of smokers with mild to moderate pulmonary obstruction, 35–60 years old, without cardiovascular comorbidity. We used C ox proportional survival analysis, controlling for several confounders, to study the effect on 5‐year risk of fatal and/or non‐fatal cardiovascular events. Secondary outcome encompassed fatal and non‐fatal coronary events. Results Of 2745 participants, 23 (0.8%) died of cardiovascular disease. One hundred and sixty‐two participants were hospitalized for a cardiovascular event, and 94 participants due to a coronary event. Survival analysis revealed no effect between smoking and short‐acting anticholinergic bronchodilation on fatal and/or non‐fatal cardiovascular events, hazard ratio = 1.12 (0.58–2.19), nor on coronary events, hazard ratio = 1.46 (0.60–3.56).Conclusions Our study results show that short‐acting anticholinergic bronchodilation had no detrimental effect on cardiovascular disease in smokers with mild to moderate pulmonary obstruction.