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Decreased activities of daily living is a strong risk factor for liver injury by anti‐tuberculosis drugs
Author(s) -
Horita Nobuyuki,
Miyazawa Naoki,
Yoshiyama Takashi,
Tsukahara Toshinori,
Takahashi Ryohei,
Tsukiji Jun,
Kato Hideaki,
Kaneko Takeshi,
Ishigatsubo Yoshiaki
Publication year - 2013
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12008
Subject(s) - medicine , regimen , liver injury , tuberculosis , odds ratio , univariate analysis , risk factor , activities of daily living , logistic regression , gastroenterology , surgery , multivariate analysis , physical therapy , pathology
Background and objective We evaluated the association between activities of daily living and drug‐induced liver injury by anti‐tuberculosis drugs. Methods This retrospective cohort study included adult inpatients with newly diagnosed smear‐positive lung tuberculosis treated with standard regimen in two hospitals. ( n = 346; 63.6 ± 20.3 years old; 106 (30.6%) females). Activities of daily living was divided into ‘independent’ ( B arthel I ndex ( BI ) 80–100, 60.4%) and ‘decreased’ ( BI 0–75, 39.6%) categories. Liver injury was defined as the withdrawal or change of treatment regimen on the basis of the following criteria: serum transaminase concentrations were more than three times the upper limit of normal range with jaundice and/or hepatitis symptoms, or more than five times the upper limit of the normal range. Results Compared with ‘independent’ patients, patients with ‘decreased’ activities of daily living had odds ratios for liver injury of 4.2 ( P < 0.001) in univariate analysis and 5.7 ( P = 0.002) in logistic regression analysis after adjusting for other risk factors. Conclusions Decreased activity of daily living is a strong risk factor for liver injury among adult inpatients with newly diagnosed smear‐positive lung tuberculosis treated using a standard regimen.