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Aberrant regulation of RNA methylation during spermatogenesis
Author(s) -
Zhong Dandan,
Chen Mengjie,
Zhang Lei,
Chen Hong,
Shi Deshun,
Liu Qingyou,
Li Hui
Publication year - 2021
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/rda.13856
Subject(s) - biology , rna , rna methylation , methylation , spermatogenesis , gene expression , dna methylation , microbiology and biotechnology , microrna , germ cell , genetics , gene , methyltransferase , endocrinology
Natural modifications of cellular RNA include various chemical modifications, such as N6 ‐methyladenosine (m 6 A), which enable the orderly metabolism and function of RNA structural diversity, thereby affecting gene expression. Spermatogenesis is a complex differentiating developmental process, which includes the proliferation of spermatogonial stem cells, spermatocyte meiosis and sperm maturation. Emerging evidence has shown that RNA methylation can influence RNA splicing, exportation and translation, which are controlled in the male germline in order to ensure coordinated gene expression. In this review, we summarize the typical characteristics of different types of RNA methylation during the process of spermatogenesis. In particular, we emphasize the functions of the RNA methylation effectors during the male germ cell development.