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Serum Levels of Cardiac Markers NT ‐pro ANP and NT ‐pro BNP in Brachycephalic bitches at Different Gestational Stages
Author(s) -
Feliciano MAR,
Uscategui RR,
Maciel GS,
Almeida VT,
Silveira MF,
Oliveira GAC,
Vicente WRR
Publication year - 2016
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/rda.12685
Subject(s) - medicine , atrial natriuretic peptide , endocrinology , natriuretic peptide , gestation , gestational age , fetus , pregnancy , brain natriuretic peptide , heart failure , biology , genetics
Contents The aim of this study was to determine serum levels of natriuretic peptide precursors ( NT ‐pro ANP and NT ‐pro BNP ) during pregnancy in brachycephalic bitches. Fifteen healthy multiparous bitches were selected for this prospective study. Serum levels of NT ‐pro ANP and NT ‐pro BNP were measured during anoestrous and at 14, 35, 42, 49 and 56 days (2nd, 5th, 6th, 7th and 8th weeks) of pregnancy. Fourteen animals had normal gestations, and one bitch developed single foetus syndrome. The natriuretic peptide levels of this animal were not included in this study; however, it is important to report that its NT ‐pro ANP levels were four times greater than those of normal patients. There was no significant difference (p = 0.072) in NT ‐pro BNP levels between anoestrous (0.20 ± 0.10 ng/ml) and the different pregnancy weeks (0.27 ± 0.12 ng/ml). There was a positive correlation (p < 0.0001) between NT ‐pro ANP and gestational age, and the levels of this marker increased significantly (p < 0.0001) during the 6th (0.26 ± 0.06 ng/ml), 7th (0.28 ± 0.04 ng/ml) and 8th weeks (0.29 ± 0.05 ng/ml) when compared to anoestrous (0.18 ± 0.02 ng/ml). NT ‐pro ANP serum levels are correlated with gestational development and may be indicative of cardiovascular adaptation in canine brachycephalic pregnancy.