Premium
Challenges and Limits Using Antimicrobial Peptides in Boar Semen Preservation
Author(s) -
Schulze M,
Grobbel M,
Müller K,
Junkes C,
Dathe M,
Rüdiger K,
Jung M
Publication year - 2015
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/rda.12553
Subject(s) - magainin , antibiotics , antimicrobial peptides , antimicrobial , antibiotic resistance , semen , antibacterial peptide , microbiology and biotechnology , artificial insemination , peptide , biology , chemistry , bacteria , biochemistry , antibacterial activity , pregnancy , genetics
Contents Antibiotics are of great importance for the preservation of ejaculates for livestock breading. The use of antibiotics, however, is not an appropriate compensation for a lack of hygiene standards in artificial insemination ( AI ) centres. Sophisticated hygiene management and the proper identification of hygienic critical control points ( HCCP s) at AI centres provide the basis for counteracting the development of antibiotic resistance in contaminant bacteria and their settlement in AI centres. In recent years, efforts have been made to use antimicrobial peptides ( AMP s) in the preservation of boar semen. Investigations have included the testing of synthetic magainin derivatives and cyclic hexapeptides. One prerequisite for the application of AMP s is that they have a minor impact on eukaryotic cells. Bacterial selectivity, proteolytic stability, thermodynamic resistance, and mechanisms including synergistic interaction with conventional antibiotics have made cyclic hexapeptides highly promising candidates for potential application as peptide antibiotics for semen preservation.