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Implication of FKBP 6 for Male Fertility in Horses
Author(s) -
Schrimpf R,
Metzger J,
Martinsson G,
Sieme H,
Distl O
Publication year - 2015
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/rda.12467
Subject(s) - fkbp , fertility , andrology , biology , endocrinology , medicine , microbiology and biotechnology , population , environmental health
Contents In stallions, impaired acrosome reaction ( IAR ) may often cause subfertility. Single nucleotide polymorphisms ( SNP s) within FK 506‐binding protein ( FKBP 6) seem to be associated with IAR in stallions. However, their effect on stallion fertility has not yet been quantified. Using whole‐genome sequence data of seven stallions, we searched FKBP 6 for mutations to perform an association study in Hanoverian stallions with estimated breeding values for the paternal component of the pregnancy rate per oestrus cycle ( EBV ‐ PAT ) as target trait. Genotyping five exonic mutations within FKBP 6 revealed a significant association of the SNP g.11040379C>A (p.167H>N) with EBV ‐ PAT in 216 Hanoverian stallions. The difference among the two homozygous genotypes was 7.62% in EBV ‐ PAT , corresponding to one standard deviation of EBV ‐ PAT . In conclusion, in Hanoverian stallions, the FKBP 6‐ associated SNP g.11040379C>A confers higher conception rates in A/A homozygous and lower conception rates in C/C homozygous Hanoverian stallions. Thus, an FKBP 6 ‐associated missense mutation is significantly associated with stallion fertility.