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Clinical Use of Deslorelin (GnRH agonist) in Companion Animals: A Review
Author(s) -
Lucas X
Publication year - 2014
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/rda.12388
Subject(s) - agonist , medicine , biology , endocrinology , receptor
Contents Over the years, many contraceptive medications have been developed for companion animals, but many secondary adverse effects have limited their use. A major advancement was achieved with the use of gonadotropin‐releasing hormone (Gn RH ) analogues, mainly Gn RH agonists, which mimic the effects of native Gn RH . The development of effective low‐dose, slow‐release implants with potent agonists such as deslorelin (Suprelorin ® , Virbac) have allowed their use to become widespread in recent years, with many potential benefits in companion animals. While the major application of deslorelin was initially male contraception, due to its two differing actions, either the stimulation of oestrus or the sterilization of fertility, its use has been increasing in the bitch as well. The aim of this study is to review the applications of deslorelin Gn RH agonist implants in companion animal, such as dogs, cats and some exotic pets.