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Lack of the Associations of the Polymorphisms in IGF 2, MC 4 R and GNAS Genes with Reproduction Traits in Pigs and Imprinting Analysis of IGF 2 Gene in Ovary and Cornus Uteri
Author(s) -
Oczkowicz M,
Mucha A,
Tyra M,
RopkaMolik K,
Piórkowska K
Publication year - 2013
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/rda.12125
Subject(s) - gnas complex locus , gene , biology , genetics
Contents In recent years, intensive attention has been put on improving reproductive performance of pigs. Several experiments aimed to identify markers associated with prolificacy, but this issue still remains open. In our study, we investigated associations between polymorphisms in IGF 2, GNAS and MC 4 R genes with reproductive traits of Polish Landrace and Large White pigs. We did not find any significant associations for g . GNAS 314T > 324C , IGF 2 intron3‐g.3072G > A or g . MC 4R 1426G > A in P olish L andrace and L arge W hite pigs. In the case of IGF 2 intron3‐g.3072G > A , this information is of great importance, because this marker is widely implemented in pigs breeding and previous experiments suggested its role in prolificacy of pigs. We also investigated expression of IGF 2 gene and showed that this gene is monoallelically expressed in reproductive organs (ovary and cornus uteri ).