z-logo
Premium
Timing of the Intestinal Barrier Closure in Puppies
Author(s) -
ChastantMaillard S,
Freyburger L,
Marcheteau E,
Thoumire S,
Ravier JF,
Reynaud K
Publication year - 2012
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/rda.12008
Subject(s) - colostrum , ingestion , passive immunity , antibody , biology , puppy , immune system , zoology , medicine , physiology , andrology , immunology , ecology
Contents As puppies are born with very low immunoglobulin concentrations, they rely on passive immune transfer from ingested colostrum to acquire a protective immunity during the first few weeks of life. The purpose of this study was to describe the timing of gut closure in canine neonates. Twenty‐two B eagle puppies received 3 ml of standardized canine colostrum at 0, 4, 8, 12, 16 or 24 h after birth using a feeding tube. Blood immunoglobulins G ( I g G , M and A ) were assayed 0, 4 and 48 h after colostrum ingestion. I g G absorption rate was significantly affected by the time of colostrum administration, and the I g G concentrations in puppies serum 48 h after administration were significantly higher when colostrum was ingested at 0–4 h of age than at 8–12 h or 16–24 h (1.68 ± 0.4, 0.79 ± 0.07 and 0.35 ± 0.08 g/l, respectively; p < 0.001). In the canine species, gut closure seems thus to begin as early as 4–8 h after birth and to be complete at 16–24 h. Consequently, this phenomenon appears to occur earlier in puppies than in most other species.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here