Premium
Lytic regulated cell death in aquaculture fish
Author(s) -
Xia Xiaojing,
He Bin,
Zhang Xiulin,
Cheng Zhe,
Liu Mingcheng,
Wei Xiaobing,
Jiang Jinqing,
Hu Jianhe
Publication year - 2021
Publication title -
reviews in aquaculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.998
H-Index - 47
eISSN - 1753-5131
pISSN - 1753-5123
DOI - 10.1111/raq.12533
Subject(s) - lytic cycle , pyroptosis , necroptosis , programmed cell death , biology , multicellular organism , disease , zebrafish , microbiology and biotechnology , aquaculture , apoptosis , ripk1 , fish <actinopterygii> , cell , gene , immunology , genetics , medicine , pathology , fishery , virus
Cell death is an important physiological and pathological phenomenon in multicellular animals and occurs widely in various body’s systems. In recent years, researchers have gained a deeper understanding of the mechanisms of necrosis and apoptosis in mammals. In addition, many new forms of lytic regulated cell death (RCD), such as pyroptosis, necroptosis and ferroptosis, have been discovered, thus enhancing our understanding of the molecular mechanisms of programmed cell death (PCD) and the associated signalling pathways as well as their relationship with diseases. However, our understanding of lytic RCD in fish is limited. Recently, some progress has been made regarding the induction conditions, expression of related genes and regulation of lytic RCD in fish. Furthermore, research on the roles of lytic RCD in tissue development, against pathogenic microorganism, inflammatory disease and neurological disease, has also been advanced. Understanding lytic RCD in fish will enable the regulation of its occurrence through human intervention to inhibit disease processes, improve fish health and explore possible countermeasures based on these basic theoretical studies.