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Amygdala response to anticipation of dyspnea is modulated by 5‐HTT LPR genotype
Author(s) -
Stoeckel M. Cornelia,
Esser Roland W.,
Gamer Matthias,
Kalisch Raffael,
Büchel Christian,
von Leupoldt Andreas
Publication year - 2015
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/psyp.12417
Subject(s) - anticipation (artificial intelligence) , psychology , amygdala , audiology , perception , affect (linguistics) , genotype , developmental psychology , association (psychology) , cognition , neuroscience , medicine , communication , chemistry , artificial intelligence , gene , biochemistry , computer science , psychotherapist
Dyspnea anticipation and perception varies largely between individuals. To investigate whether genetic factors related to negative affect such as the 5‐HTT LPR polymorphism impact this variability, we investigated healthy, 5‐HTT LPR stratified volunteers using resistive load induced dyspnea together with fMRI. Alternating blocks of severe and mild dyspnea (“perception”) were differentially cued (“anticipation”) and followed by intensity and unpleasantness ratings. In addition, volunteers indicated their anticipatory fear during the anticipation periods. There were no genotype‐based group differences concerning dyspnea intensity and unpleasantness or brain activation during perception of severe vs. mild dyspnea. However, in risk allele carriers, higher anticipatory fear was paralleled by stronger amygdala activation during anticipation of severe vs. mild dyspnea. These results suggest a role of the 5‐HTT LPR genotype in fearful dyspnea anticipation.