Premium
Hyperactive auditory processing in Williams syndrome: Evidence from auditory evoked potentials
Author(s) -
Zarchi Omer,
Avni Chen,
Attias Josef,
Frisch Amos,
Carmel Miri,
Michaelovsky Elena,
Green Tamar,
Weizman Abraham,
Gothelf Doron
Publication year - 2015
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/psyp.12407
Subject(s) - mismatch negativity , psychology , audiology , cognition , williams syndrome , comprehension , auditory perception , developmental psychology , electroencephalography , perception , neuroscience , medicine , linguistics , philosophy
The neurophysiologic aberrations underlying the auditory hypersensitivity in Williams syndrome (WS) are not well defined. The P1‐N1‐P2 obligatory complex and mismatch negativity (MMN) response were investigated in 18 participants with WS, and the results were compared with those of 18 age‐ and gender‐matched typically developing (TD) controls. Results revealed significantly higher amplitudes of both the P1‐N1‐P2 obligatory complex and the MMN response in the WS participants than in the TD controls. The P1‐N1‐P2 complex showed an age‐dependent reduction in the TD but not in the WS participants. Moreover, high P1‐N1‐P2 complex was associated with low verbal comprehension scores in WS. This investigation demonstrates that central auditory processing is hyperactive in WS. The increase in auditory brain responses of both the obligatory complex and MMN response suggests aberrant processes of auditory encoding and discrimination in WS. Results also imply that auditory processing may be subjected to a delayed or diverse maturation and may affect the development of high cognitive functioning in WS.