Premium
A mechanism of deficient interregional neural communication in schizophrenia
Author(s) -
Popov Tzvetan,
Wienbruch Christian,
Meissner Sarah,
Miller Gregory A.,
Rockstroh Brigitte
Publication year - 2015
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/psyp.12393
Subject(s) - psychology , schizophrenia (object oriented programming) , neuroscience , mechanism (biology) , electroencephalography , anterior cingulate cortex , neuroimaging , cognition , error related negativity , interference (communication) , psychiatry , philosophy , channel (broadcasting) , epistemology , electrical engineering , engineering
Cognitive interference control is disrupted in schizophrenia ( SZ ). Neuroimaging studies relate interference control to 4–7 Hz (theta) neural activity in a network spanning prefrontal, anterior cingulate ( ACC ), and parietal cortices. The mechanism of communication in this network and how it is disrupted in schizophrenia are unclear. Behavioral performance and EEG theta oscillations were examined in a S troop color‐word interference task in 17 healthy controls ( HC ) and 14 SZ patients. Color‐word incongruence induced less theta power increase in SZ than in HC around 400 ms and 600–900 ms after word onset in ACC , left middle frontal gyrus ( MFG ), and inferior parietal regions. Coupling of ACC theta phase to MFG gamma amplitude, indexing interregional communication, was weaker in SZ than in HC . Results suggest ACC‐MFG theta power modulation as a mechanism of interference control that supports executive function and is disrupted in schizophrenia.