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Lipopolysaccharide‐binding protein and leptin are associated with stress‐induced interleukin‐6 cytokine expression ex vivo in obesity
Author(s) -
Huang ChunJung,
Stewart Jennifer K.,
Shibata Yoshimi,
Slusher Aaron L.,
Acevedo Edmund O.
Publication year - 2015
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/psyp.12387
Subject(s) - leptin , cytokine , lipopolysaccharide , inflammation , medicine , endocrinology , obesity , immune system , interleukin 6 , ex vivo , immunology , sickness behavior , psychology , in vivo , biology , microbiology and biotechnology
Obesity is associated with enhanced inflammation and mental stress, but limited information has addressed the potential additive effect of psychological stress on obesity‐associated inflammation. This study examined whether obese subjects would elicit a greater host immune response ( IL ‐6 m RNA and cytokine) to lipopolysaccharide ( LPS ) in response to mental stress. Blood samples for LPS ‐stimulated IL ‐6 m RNA and cytokine were collected prior to and following mental stress. Results showed that obese subjects elicited a greater LPS ‐induced IL ‐6 along with its m RNA expression following mental stress compared to normal‐weight subjects. Stress‐induced IL ‐6 cytokine response to LPS was correlated with the baseline levels of plasma LPS binding protein ( LBP ) and leptin. These findings are consistent with the idea that endogenous inflammatory agents (e.g., LBP and leptin), often elevated with obesity, enhance inflammatory responses to psychological stress.