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Genetics, neuroscience, and psychopathology: Clothing the emperor
Author(s) -
Patrick Christopher J.
Publication year - 2014
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/psyp.12356
Subject(s) - endophenotype , psychology , psychopathology , neurocognitive , biological psychopathology , prepulse inhibition , cognitive psychology , schizophrenia (object oriented programming) , developmental psychology , neuroscience , clinical psychology , cognition , developmental psychopathology , psychiatry
This ground‐breaking series of articles reports findings from genome‐wide analyses of endophenotypic indicators of psychopathology including electrocortical activity/reactivity, electrodermal and startle blink responses, and neurocognitive task performance. Findings challenge the long‐held notion that endophenotypes more clearly reflect the impact of specific genes than referent clinical phenotypes. Implications for the concept of endophenotypes and biological psychopathology research more broadly are discussed.