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Heritability and molecular‐genetic basis of the P 3 event‐related brain potential: A genome‐wide association study
Author(s) -
Malone Stephen M.,
Vaidyanathan Uma,
Basu Saonli,
Miller Michael B.,
MCGUE Matt,
Iacono William G.
Publication year - 2014
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/psyp.12345
Subject(s) - endophenotype , genome wide association study , heritability , single nucleotide polymorphism , genetic association , psychology , candidate gene , genetics , additive genetic effects , gene , biology , genotype , neuroscience , cognition
P3 amplitude is a candidate endophenotype for disinhibitory psychopathology, psychosis, and other disorders. The present study is a comprehensive analysis of the behavioral‐ and molecular‐genetic basis of P3 amplitude and a P3 genetic factor score in a large community sample ( N = 4,211) of adolescent twins and their parents, genotyped for 527,829 single nucleotide polymorphisms ( SNP s). Biometric models indicated that as much as 65% of the variance in each measure was due to additive genes. All SNP s in aggregate accounted for approximately 40% to 50% of the heritable variance. However, analyses of individual SNP s did not yield any significant associations. Analyses of individual genes did not confirm previous associations between P 3 amplitude and candidate genes but did yield a novel association with myelin expression factor 2 ( MYEF 2 ). Main effects of individual variants may be too small to be detected by GWAS without larger samples.