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Abnormal interactions between context, memory structure, and mood in schizophrenia: An ERP investigation
Author(s) -
Pinheiro Ana P.,
Del Re Elisabetta,
Nestor Paul G.,
Mezin Jenna,
Rezaii Neguine,
McCarley Robert W.,
Gonçalves Óscar F.,
Niznikiewicz Margaret
Publication year - 2015
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/psyp.12289
Subject(s) - psychology , schizophrenia (object oriented programming) , mood , context (archaeology) , sentence , semantic memory , cognitive psychology , developmental psychology , cognition , neuroscience , clinical psychology , psychiatry , linguistics , biology , paleontology , philosophy
Abstract This study used event‐related potentials to examine interactions between mood, sentence context, and semantic memory structure in schizophrenia. Seventeen male chronic schizophrenia and 15 healthy control subjects read sentence pairs after positive, negative, or neutral mood induction. Sentences ended with expected words ( EW ), within‐category violations ( WCV ), or between‐category violations ( BCV ). Across all moods, patients showed sensitivity to context indexed by reduced N 400 to EW relative to both WCV and BCV . However, they did not show sensitivity to the semantic memory structure. N 400 abnormalities were particularly enhanced under a negative mood in schizophrenia. These findings suggest abnormal interactions between mood, context processing, and connections within semantic memory in schizophrenia, and a specific role of negative mood in modulating semantic processes in this disease.