Premium
Diagnostic specificity and familiality of early versus late evoked potentials to auditory paired stimuli across the schizophrenia‐bipolar psychosis spectrum
Author(s) -
Hamm Jordan P.,
Ethridge Lauren E.,
Boutros Nashaat N.,
Keshavan Matcheri S.,
Sweeney John A.,
Pearlson Godfrey D.,
Tamminga Carol A.,
Clementz Brett A.
Publication year - 2014
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/psyp.12185
Subject(s) - psychology , psychosis , bipolar disorder , proband , audiology , schizophrenia (object oriented programming) , electroencephalography , developmental psychology , neuroscience , psychiatry , cognition , medicine , biochemistry , chemistry , mutation , gene
Disrupted sensory processing is a core feature of psychotic disorders. Auditory paired stimuli ( PS ) evoke a complex neural response, but it is uncertain which aspects reflect shared and/or distinct liability for the most common severe psychoses, schizophrenia ( SZ ) and psychotic bipolar disorder ( BDP ). Evoked time‐voltage/time‐frequency domain responses quantified with EEG during a typical PS paradigm (S1‐S2) were compared among proband groups ( SZ [ n = 232], BDP [181]), their relatives ( SZrel [259], BDPrel [220]), and healthy participants ( H [228]). Early S1‐evoked responses were reduced in SZ and BDP , while later/S2 abnormalities showed SZ / SZrel and BDP / BDPrel specificity. Relatives' effects were absent/small despite significant familiality of the entire auditorineural response. This pattern suggests general and divergent biological pathways associated with psychosis, yet may reflect complications with conditioning solely on clinical phenomenology.