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Neural correlates of impaired volitional action control in schizophrenia patients
Author(s) -
Bender Julia,
Reuter Benedikt,
Möllers David,
Kaufmann Christian,
Gallinat Jürgen,
Kathmann Norbert
Publication year - 2013
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/psyp.12060
Subject(s) - psychology , functional magnetic resonance imaging , schizophrenia (object oriented programming) , eye movement , audiology , neuroscience , gaze , action (physics) , prefrontal cortex , cognitive psychology , cognition , psychiatry , medicine , physics , quantum mechanics , psychoanalysis
Slowed initiation of volitional but not visually guided saccades indicates impaired volitional action control in schizophrenia patients ( SZ ). The present study aimed at identifying neural correlates of this specific deficit. Fourteen SZ and 13 healthy control participants ( HC ) underwent functional magnetic resonance imaging while performing volitional and visually guided saccades. SZ showed increased latencies in volitional but not in visually guided saccades. Brain activation during volitional saccades compared to visually guided saccades was increased in SZ compared to HC in several areas: the supplementary eye fields, suggesting inefficient production of volitional saccades; the prefrontal cortex, pointing to altered top down control on complex eye movements; and the left middle temporal area, suggesting changes in early sensory and attention processing during the volitional control of saccades in SZ .