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Hemodynamic, hemostatic, and endothelial reactions to acute psychological stress in depressed patients following coronary angiography
Author(s) -
Plourde Annik,
Lavoie Kim L.,
Ouellet Karine,
Carroll Douglas,
Ring Christopher,
Bacon Simon L.
Publication year - 2013
Publication title -
psychophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.661
H-Index - 156
eISSN - 1469-8986
pISSN - 0048-5772
DOI - 10.1111/psyp.12059
Subject(s) - impedance cardiography , hemodynamics , cardiology , depression (economics) , psychology , coronary artery disease , medicine , blood pressure , heart rate , stroke volume , economics , macroeconomics
Although there is evidence that depression is associated with an increased risk for coronary artery disease ( CAD ), the mechanisms underlying this association remain unclear. This study examined the association between depression and hemodynamic, hemostatic, and endothelial responses to psychological stress. Seventy‐two postcoronary angiography patients completed a mental stress task. Blood pressure, heart rate, and impedance cardiography were recorded at rest and during the task. Blood samples were taken at the end of rest and immediately after the task. Depression was evaluated using the D iagnostic I nterview S chedule S elf‐ A dministered ( DISSA ). In total, 21% of the participants were depressed. Analyses revealed that depression was associated with blunted pre‐ejection period stress reactivity and with increased platelet factor 4 reactivity. These data provide potential mechanistic pathways linking depression to increased CAD .