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A systematic review of atypical Alzheimer's disease including behavioural and psychological symptoms
Author(s) -
Shea YatFung,
Pan Yining,
Mak Henry KaFung,
Bao Yiwen,
Lee ShuiChing,
Chiu Patrick KaChun,
Chan HonWai Felix
Publication year - 2021
Publication title -
psychogeriatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 32
eISSN - 1479-8301
pISSN - 1346-3500
DOI - 10.1111/psyg.12665
Subject(s) - posterior cortical atrophy , corticobasal degeneration , dementia , disease , primary progressive aphasia , medicine , psychology , frontotemporal dementia , psychiatry , clinical psychology , pathology
Alzheimer's disease (AD) is the commonest cause of dementia, characterized by the clinical presentation of progressive anterograde episodic memory impairment. However, atypical presentation of patients is increasingly recognized. These atypical AD include logopenic aphasia, behavioural variant AD, posterior cortical atrophy, and corticobasal syndrome. These atypical AD are more common in patients with young onset AD before the age of 65 years old. Since medical needs (including the behavioural and psychological symptoms of dementia) of atypical AD patients could be different from typical AD patients, it is important for clinicians to be aware of these atypical forms of AD. In addition, disease modifying treatment may be available in the future. This review aims at providing an update on various important subtypes of atypical AD including behavioural and psychological symptoms.