Premium
Cerebral blood flow and Alzheimer's disease‐related biomarkers in cerebrospinal fluid in idiopathic normal pressure hydrocephalus
Author(s) -
Azuma Shingo,
Kazui Hiroaki,
Kanemoto Hideki,
Suzuki Yukiko,
Sato Shunsuke,
Suehiro Takashi,
Matsumoto Takuya,
Yoshiyama Kenji,
Kishima Haruhiko,
Shimosegawa Eku,
Tanaka Toshihisa,
Ikeda Manabu
Publication year - 2019
Publication title -
psychogeriatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 32
eISSN - 1479-8301
pISSN - 1346-3500
DOI - 10.1111/psyg.12435
Subject(s) - medicine , cerebral blood flow , putamen , precuneus , cerebrospinal fluid , parahippocampal gyrus , cardiology , dementia with lewy bodies , dementia , temporal lobe , pathology , radiology , disease , psychiatry , epilepsy , functional magnetic resonance imaging
Aim Alzheimer's disease (AD) pathology is highly prevalent in patients with idiopathic normal pressure hydrocephalus (iNPH), and the presence of AD pathology may involve regional cerebral blood flow (rCBF). In this study, we examined the relationship between rCBF and AD‐related biomarkers in the cerebrospinal fluid of iNPH patients. Methods Patients with iNPH ( n = 39) were classified into groups with (iNPH/AD+) ( n =15) and without (iNPH/AD−) ( n =24) high biomarker probability of AD (i.e. combined low amyloid β 42 and high total tau in the cerebrospinal fluid). rCBF was quantified in 17 regions of interest by N‐isopropyl‐p‐[ 123 I]iodoamphetamine single‐photon emission computed tomography with the autoradiography method. We compared rCBF between the iNPH/AD− and iNPH/AD+ groups at baseline using a t ‐test and then compared changes in rCBF after shunt surgery between the groups using a paired t ‐test and two‐way repeated measures ANOVA. Results At baseline, there were no significant differences in rCBF between the groups in most regions apart from the putamen. After shunt surgery, a significant increase in rCBF in the putamen, amygdala, hippocampus, and parahippocampal gyrus was observed in iNPH/AD− patients. In iNPH/AD+ patients, no significant improvement in rCBF was observed in any region. In repeated measures analysis of variance, a significant group × shunt interaction was observed in the parietal lobe, frontal lobe, posterior cingulate cortex, precuneus, lateral temporal lobe, amygdala, hippocampus, parahippocampal gyrus, and putamen. Conclusions Improvement in rCBF after shunt surgery in iNPH/AD+ patients may be poorer than that in iNPH AD− patients.