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Concurrent antipsychotic use in older adults treated with antidepressants in Asia
Author(s) -
Dong Min,
Zeng LiangNan,
Zhang Qinge,
Ungvari Gabor S.,
Ng Chee H.,
Chiu Helen F. K.,
Si TianMei,
Sim Kang,
Avasthi Ajit,
Grover Sandeep,
Chong MianYoon,
Chee KokYoon,
Kanba Shigenobu,
Lee MinSoo,
Yang ShuYu,
Udomratn Pichet,
Kallivayalil Roy A.,
Tanra Andi J.,
Maramis Margarita M.,
Shen Winston W.,
Sartorius Norman,
Mahendran Rathi,
Tan ChayHoon,
Shinfuku Naotaka,
Xiang YuTao
Publication year - 2019
Publication title -
psychogeriatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 32
eISSN - 1479-8301
pISSN - 1346-3500
DOI - 10.1111/psyg.12416
Subject(s) - logistic regression , psychiatry , antipsychotic , medicine , schizophrenia (object oriented programming) , multivariate analysis , anxiety , population , depression (economics) , demography , environmental health , macroeconomics , sociology , economics
Aim Depressive disorders are common in old age. Antipsychotics (APs) are often used as an adjunctive treatment with antidepressants (ADs) in this population but its patterns of use in Asia are not known. This study explored the rate of combination of APs and ADs in older adult psychiatric patients in Asia. Methods This is a secondary analysis of the database of a multicentre study which recorded participants’ basic demographical and clinical data in standardised format in 10 Asian countries and territories. The data were analysed using univariate and multivariate logistic regression analyses. Results A total of 955 older adult psychiatric in‐ and outpatients were included in this study. The proportion of concurrent AP and AD use was 32.0%, ranging from 23.3% in Korea to 44.0% in Taiwan. Multivariate logistic regression analysis found that younger age, inpatient status and diagnosis of schizophrenia, anxiety and other mental disorders were significantly related to a higher proportion of concurrent use of APs and ADs. Conclusion Around a third of older adult psychiatric patients had concurrent AP and AD use in the Asian countries/regions surveyed. Considering the uncertain effectiveness and questionable safety of the AP and AD combination in this patient population, such should be cautiously used.