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Alpha event‐related synchronization after eye closing differs in Alzheimer's disease and dementia with Lewy bodies: a magnetoencephalography study
Author(s) -
Hata Masahiro,
Kurimoto Ryu,
Kazui Hiroaki,
Ishii Ryouhei,
Canuet Leonides,
Aoki Yasunori,
Ikeda Shunichiro,
Azuma Shingo,
Suehiro Takashi,
Sato Shunsuke,
Suzuki Yukiko,
Kanemoto Hideki,
Yoshiyama Kenji,
Iwase Masao,
Ikeda Manabu
Publication year - 2018
Publication title -
psychogeriatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 32
eISSN - 1479-8301
pISSN - 1346-3500
DOI - 10.1111/psyg.12313
Subject(s) - dementia with lewy bodies , magnetoencephalography , electroencephalography , dementia , alpha (finance) , medicine , neuroscience , audiology , alzheimer's disease , psychology , disease , pathology , surgery , construct validity , patient satisfaction
Background The electroencephalography (EEG) abnormalities found in patients with dementia with Lewy bodies (DLB) are conflicting. In this study, we used magnetoencephalography, which has higher spatial resolution than electroencephalography, to explore neurophysiological features of DLB that may aid in the differential diagnosis. Methods Six patients with DLB, 11 patients with Alzheimer's disease, and 11 age‐matched normal subjects were recruited. We investigated alterations in the ratio of event‐related synchronization (ERS) in the alpha band after eye‐closing. Results Although the averaged ratio change of alpha ERS after eye‐closing appeared predominantly in the posterior brain regions in all study groups, DLB patients had the weakest ratio change of alpha ERS. In particular, DLB patients exhibited a significantly reduced ratio change of alpha ERS in the bilateral inferior temporal gyrus, right occipital pole, and left parieto‐occipital cortex compared to Alzheimer's disease patients or normal controls. Conclusion Our findings indicated that a reduced ratio change of alpha ERS in the posterior brain regions elicited by eye‐closing is a brain electromagnetic feature of DLB.