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Comparing the neuropsychological profiles of mild dementia with L ewy bodies and mild A lzheimer’s disease
Author(s) -
Xu Yan,
Chen Keliang,
Zhao Qianhua,
Guo Qihao
Publication year - 2018
Publication title -
psychogeriatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 32
eISSN - 1479-8301
pISSN - 1346-3500
DOI - 10.1111/psyg.12293
Subject(s) - neuropsychology , dementia , neuropsychological test , medicine , cognition , recall , disease , alzheimer's disease , discriminant function analysis , audiology , psychology , psychiatry , clinical psychology , cognitive psychology , computer science , machine learning
Background The present study was conducted to detect neuropsychological differences and to identify discriminators between mild dementia with L ewy bodies ( DLB ) and mild A lzheimer’s disease ( AD ). Methods The present study included 37 mild DLB patients, 48 mild AD patients, and 80 healthy elderly individuals. A comprehensive battery of neuropsychological tests was administrated to assess their cognitive function. Linear stepwise discriminant analysis was used to identify the neuropsychological measures with values that could differentiate between mild DLB and mild AD . Results The mild DLB group had greater impairments in attention, executive function, and visuospatial ability, while mild AD patients performed significantly worse on memory tests. Linear stepwise discriminant analysis indicated that the M emory and E xecutive S creening’s 5‐min delayed recall test was the best neuropsychological discriminator between mild DLB and mild AD . Conclusions Different patterns of cognitive impairment facilitate the differentiation of mild DLB from mild AD . For patients with mild dementia, better performance on the M emory and E xecutive S creening’s 5‐min delayed recall test suggests that the diagnosis is more likely DLB than AD .