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Differences in the neural correlates of frontal lobe tests
Author(s) -
Matsuoka Teruyuki,
Kato Yuka,
Imai Ayu,
Fujimoto Hiroshi,
Shibata Keisuke,
Nakamura Kaeko,
Yamada Kei,
Narumoto Jin
Publication year - 2018
Publication title -
psychogeriatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 32
eISSN - 1479-8301
pISSN - 1346-3500
DOI - 10.1111/psyg.12285
Subject(s) - frontal lobe , neural correlates of consciousness , psychology , neuroscience , cognitive psychology , cognition
Background The Executive Interview ( EXIT 25), the e xecutive c lock‐ d rawing t ask ( CLOX 1), and the F rontal A ssessment B attery ( FAB ) are used to assess executive function at the bedside. These tests assess distinct psychometric properties. The aim of this study was to examine differences in the neural correlates of the EXIT 25, CLOX 1, and FAB based on m agnetic r esonance i maging. Methods Fifty‐eight subjects (30 with A lzheimer’s disease, 10 with mild cognitive impairment, and 18 healthy controls) participated in this study. Multiple regression analyses were performed to examine the brain regions correlated with the EXIT 25, CLOX 1, and FAB scores. Age, gender, and years of education were included as covariates. Statistical thresholds were set to uncorrected P ‐values of 0.001 at the voxel level and 0.05 at the cluster level. Results The EXIT 25 score correlated inversely with the regional grey matter volume in the left lateral frontal lobe ( B rodmann areas 6, 9, 44, and 45). The CLOX 1 score correlated positively with the regional grey matter volume in the right orbitofrontal cortex ( B rodmann area 11) and the left supramarginal gyrus ( B rodmann area 40). The FAB score correlated positively with the regional grey matter volume in the right precentral gyrus ( B rodmann area 6). The left lateral frontal lobe ( B rodmann area 9) and the right lateral frontal lobe ( B rodmann area 46) were identified as common brain regions that showed association with EXIT 25, CLOX 1, and FAB based only a voxel‐level threshold. Conclusions The results of this study suggest that the EXIT 25, CLOX 1, and FAB may be associated with the distinct neural correlates of the frontal cortex.