Effectiveness of low‐dose pregabalin in three patients with L ewy body disease and central neuropathic pain

Many patients with L ewy body disease complain of pain, and their pain may be associated with this disease. Recently, pain has become a focus of attention in P arkinson's disease, but there is little information regarding pain in patients who have dementia with L ewy bodies. We used pregabalin to treat three L ewy body disease patients with chronic pain that may have been related to degeneration of central neurons. All three patients responded well to pregabalin at 25–50 mg/day. To our knowledge, there have been no previous reports of pregabalin showing efficacy for central neuropathic pain in P arkinson's disease or L ewy body disease.