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Serum insulin‐like growth factor‐I and amyloid beta protein in Alzheimer's disease: relationship with cognitive function
Author(s) -
Kimoto Ayako,
Kasanuki Koji,
Kumagai Ryo,
Shibata Nobuto,
Ichimiya Yosuke,
Arai Heii
Publication year - 2016
Publication title -
psychogeriatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 32
eISSN - 1479-8301
pISSN - 1346-3500
DOI - 10.1111/psyg.12149
Subject(s) - medicine , dementia , mini–mental state examination , cognition , alzheimer's disease , neuropsychology , pathogenesis , disease , psychology , verbal fluency test , insulin like growth factor , endocrinology , gastroenterology , psychiatry , growth factor , receptor
Aims Previous studies have suggested that insulin‐like growth factor‐I ( IGF ‐I) deficiency may lead to cognitive deficits in neurodegenerative diseases such as Alzheimer's disease. The present study aimed to investigate the possible relationship between cognitive function and concentration of IGF ‐I or amyloid beta protein ( Aβ ) in serum in Alzheimer's patients.Methods A total of 81 Japanese patients were enrolled in this study. Concentrations of IGF ‐I, Aβ42 , and Aβ40 in serum were measured. Two neuropsychological tests, Mini‐Mental State Examination and Hasegawa's Dementia Scale‐Revised ( HDS ‐R), were also performed. Linear correlations among the age, serum IGF ‐I, serum Aβ42 or Aβ40 , Aβ42 / Aβ40 ratio, Mini‐Mental State Examination or HDS ‐R total score, and the scores for six HDS ‐R subscales were analyzed by regression analysis.Results IGF ‐I showed a significant negative correlation with age (β = −0.357, P = 0.002) and a positive correlation with Aβ42 / Aβ40 ratio (β = 0.318, P = 0.007). Serum IGF ‐I and both the Mini‐Mental State Examination and the HDS ‐R total score also correlated (β = 0.505, β = 0.524, P < 0.01). Among the HDS ‐R subscales, ‘Recall’ (ρ = 0.379, P < 0.01), ‘Verbal fluency’ (ρ = 0.360, P < 0.01), and ‘Attention and calculation’ (ρ = 0.389, P < 0.01) showed significant positive correlations with serum IGF ‐I.Conclusion The results, specifically that lower serum IGF ‐I was associated with cognitive impairment, suggest that metabolism of IGF ‐I may be involved in the pathogenesis of cognitive deficits in Alzheimer's disease.