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Apolipoprotein E genotype modulates effects of vitamin B 12 and homocysteine on grey matter volume in A lzheimer's disease
Author(s) -
Lee YoungMin,
Ha JiKyung,
Park JeMin,
Lee ByungDae,
Moon EunSoo,
Chung YoungIn,
Kim JiHoon,
Kim HakJin,
Mun ChiWoong,
Kim TaeHyung,
Kim YoungHoon
Publication year - 2016
Publication title -
psychogeriatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 32
eISSN - 1479-8301
pISSN - 1346-3500
DOI - 10.1111/psyg.12109
Subject(s) - homocysteine , apolipoprotein e , vitamin b12 , medicine , endocrinology , genotype , grey matter , magnetic resonance imaging , chemistry , psychology , immunology , disease , biochemistry , white matter , radiology , gene
Aims The aim of the present study was to investigate whether the effects of vitamin B 12 and homocysteine on brain volume are influenced by apolipoprotein E ( APOE ) genotype. We examined the effects in each subgroup ( APOE ε4 carriers and non‐carriers) of A lzheimer's disease ( AD ) patients and healthy normal controls. Methods Forty participants with AD and 20 healthy normal controls were recruited from memory impairment clinics at P usan N ational U niversity H ospital in K orea. All participants were APOE genotyped and underwent magnetic resonance imaging, including 3‐D volumetric images for grey matter ( GM ) volume. A multiple regression model integrated into statistical parametric mapping was used to see if there was any correlation between vitamin B 12 or homocysteine and GM volume in each subgroup ( APOE ε4 carriers and non‐carriers) of AD patients and healthy normal controls. Results There was a significant positive correlation between serum concentrations of vitamin B 12 and regional GM volume in APOE ε4 carriers with AD but not in non‐carriers. We also found that there was a significant negative correlation between serum concentrations of homocysteine and regional GM volume in APOE ε4 non‐carriers with AD but not in carriers ( P < 0.001, uncorrected for multiple comparisons; extent threshold = 100 voxel). Conclusion The present findings suggest that the effects of vitamin B 12 and homocysteine on GM volume might be influenced by APOE genotype.