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Myeloid‐derived suppressor cells in obesity‐associated periodontal disease: A conceptual model
Author(s) -
Kwack Kyu Hwan,
Maglaras Victoria,
Thiyagarajan Ramkumar,
Zhang Lixia,
Kirkwood Keith L.
Publication year - 2021
Publication title -
periodontology 2000
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.725
H-Index - 122
eISSN - 1600-0757
pISSN - 0906-6713
DOI - 10.1111/prd.12384
Subject(s) - medicine , periodontitis , disease , obesity , myeloid , population , inflammation , incidence (geometry) , immunology , dentistry , pathology , environmental health , physics , optics
Periodontitis is a common chronic inflammatory disease characterized by destruction of the supporting structures of the teeth. Severe periodontitis is highly prevalent—affecting 10%‐15% of adults—and carries several negative comorbidities, thus reducing quality of life. Although a clear relationship exists between severity of obesity and incidence of periodontal disease, the biologic mechanisms that support this link are incompletely understood. In this conceptual appraisal, a new “two‐hit” model is presented to explain obesity‐exacerbated periodontal bone loss. This proposed model recognizes a previously unappreciated aspect of myeloid‐derived suppressor cell population expansion, differentiation, and activity that can participate directly in periodontal bone loss, providing new mechanistic and translational perspectives.