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Periodontal health and disease: The contribution of genetics
Author(s) -
Shaddox Luciana Macchion,
Morford Lorri Ann,
Nibali Luigi
Publication year - 2021
Publication title -
periodontology 2000
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.725
H-Index - 122
eISSN - 1600-0757
pISSN - 0906-6713
DOI - 10.1111/prd.12357
Subject(s) - disease , medicine , epigenetics , periodontitis , pathogenesis , periodontal disease , human genetics , bioinformatics , genetics , immunology , biology , pathology , gene , dentistry
Periodontitis is an infectious, inflammatory disease that is associated with a complex interplay between specific bacteria, host response, and environmental factors. Because of its high degree of familial aggregation, specifically for the more aggressive forms of the disease, genetics factors have been implicated in disease pathogenesis for several decades. This review provides an overview of what we currently know regarding the genetic and epigenetic contributions to periodontal disease and discusses future opportunities in the field.