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Wound healing following surgical and regenerative periodontal therapy
Author(s) -
Susin Cristiano,
Fiorini Tiago,
Lee Jaebum,
De Stefano Jamie A.,
Dickinson Douglas P.,
Wikesjö Ulf M. E.
Publication year - 2015
Publication title -
periodontology 2000
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.725
H-Index - 122
eISSN - 1600-0757
pISSN - 0906-6713
DOI - 10.1111/prd.12057
Subject(s) - medicine , periodontium , regeneration (biology) , wound healing , limiting , intensive care medicine , regenerative medicine , dentistry , bioinformatics , surgery , stem cell , mechanical engineering , genetics , engineering , biology , microbiology and biotechnology
Clinical studies have evaluated the effect of conventional periodontal surgical therapy. In general, although some clinical gain in tissue support may be attained, these therapies do not support regeneration of the periodontal attachment. Even though the biological possibility of periodontal regeneration has been demonstrated, the clinical application of this intrinsic potential appears difficult to harness; thus also conceptually most intriguing candidate protocols face clinical challenges. In this review, we explore the bioclinical principles, condiciones sine quibus non , that unleash the innate potential of the periodontium to achieve clinically meaningful periodontal regeneration (i.e. space‐provision, wound stability and conditions for primary intention healing). Moreover, limiting factors and detrimental practices that may compromise clinical and biological outcomes are reviewed, as is tissue management in clinical settings.