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Role of integrins in the periodontal ligament: organizers and facilitators
Author(s) -
Barczyk Malgorzata,
Bolstad Anne Isine,
Gullberg Donald
Publication year - 2013
Publication title -
periodontology 2000
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.725
H-Index - 122
eISSN - 1600-0757
pISSN - 0906-6713
DOI - 10.1111/prd.12027
Subject(s) - periodontal fiber , medicine , regenerative medicine , dentistry , ligament , mineralized tissues , stem cell , anatomy , microbiology and biotechnology , biology , dentin
The periodontal ligament is the tissue that connects teeth to bone. The periodontal ligament is a fascinating tissue from a cell biologist's point of view, and because of its special properties and stem‐cell content it has also come into the limelight in emerging fields of regenerative medicine. An increased range of genetically modified mouse models offer new tools for studying molecular mechanisms of tooth development. However, owing to species‐specific organization of the tooth apparatus, the use of genetic animal models to study the role of the periodontal ligament in normal human tooth physiology and tooth pathology is challenging.