Premium
Cell adhesion proteins: roles in periodontal physiology and discovery by proteomics
Author(s) -
Wang Yongqiang,
Wang Qin,
D. Arora Pamma,
Rajshankar Dhaarmini,
McCulloch Christopher A.
Publication year - 2013
Publication title -
periodontology 2000
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.725
H-Index - 122
eISSN - 1600-0757
pISSN - 0906-6713
DOI - 10.1111/prd.12026
Subject(s) - connective tissue , microbiology and biotechnology , extracellular matrix , cell adhesion molecule , cell adhesion , proteomics , medicine , regeneration (biology) , adhesion , cell , function (biology) , bioinformatics , biology , pathology , biochemistry , chemistry , organic chemistry , gene
Adhesion molecules expressed by periodontal connective tissue cells are involved in cell migration, matrix remodeling and inflammatory responses to infection. Currently, the processes by which the biologic activity of these molecules are appropriately regulated in time and space to preserve tissue homeostasis, and to control inflammatory responses and tissue regeneration, are not defined. As cell adhesions are heterogeneous, dynamic, contain a complex group of interacting molecules and are strongly influenced by the type of substrate to which they adhere, we focus on how cell adhesions in periodontal connective tissues contribute to information generation and processing that regulate periodontal structure and function. We also consider how proteomic methods can be applied to discover novel cell‐adhesion proteins that could potentially contribute to the form and function of periodontal tissues.