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Harnessing transcription for bioproduction in cyanobacteria
Author(s) -
Stensjö Karin,
Vavitsas Konstantinos,
Tyystjärvi Taina
Publication year - 2018
Publication title -
physiologia plantarum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.351
H-Index - 146
eISSN - 1399-3054
pISSN - 0031-9317
DOI - 10.1111/ppl.12606
Subject(s) - bioproduction , cyanobacteria , synthetic biology , metabolic engineering , biology , computational biology , exploit , transcription (linguistics) , biochemical engineering , microbiology and biotechnology , gene , bacteria , computer science , genetics , engineering , linguistics , philosophy , computer security
Sustainable production of biofuels and other valuable compounds is one of our future challenges. One tempting possibility is to use photosynthetic cyanobacteria as production factories. Currently, tools for genetic engineering of cyanobacteria are not good enough to exploit the full potential of cyanobacteria. A wide variety of expression systems will be required to adjust both the expression of heterologous enzyme(s) and metabolic routes to the best possible balance, allowing the optimal production of a particular substance. In bacteria, transcription, especially the initiation of transcription, has a central role in adjusting gene expression and thus also metabolic fluxes of cells according to environmental cues. Here we summarize the recent progress in developing tools for efficient cyanofactories, focusing especially on transcriptional regulation.