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Systems biology approaches to understand the role of auxin in root growth and development
Author(s) -
Goh Tatsuaki,
Voβ Ute,
Farcot Etienne,
Bennett Malcolm J.,
Bishopp Anthony
Publication year - 2014
Publication title -
physiologia plantarum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.351
H-Index - 146
eISSN - 1399-3054
pISSN - 0031-9317
DOI - 10.1111/ppl.12162
Subject(s) - auxin , multicellular organism , biology , context (archaeology) , computational biology , systems biology , robustness (evolution) , signalling , plant development , plant growth , signalling pathways , biochemical engineering , microbiology and biotechnology , botany , signal transduction , engineering , biochemistry , gene , paleontology
The past decade has seen major advances in our understanding of auxin regulated root growth and developmental processes. Key genes have been identified that regulate and/or mediate auxin homeostasis, transport, perception and response. The molecular and biochemical reactions that underpin auxin signalling are non‐linear, with feed‐forward and feedback loops contributing to the robustness of the system. As our knowledge of auxin biology becomes increasingly complex and their outputs less intuitive, modelling is set to become much more important. For the last several decades modelling efforts have focused on auxin transport and, latterly, on auxin response. Recently researchers have employed multi‐scale modelling approaches to predict emergent properties at the tissue and organ scales. Such innovative modelling approaches are proving very promising, revealing new mechanistic insights about how auxin functions within a multicellular context to control plant growth and development. In this review we initially describe examples of models capturing auxin transport and response pathways, and then discuss increasingly complex models that integrate multiple hormone response pathways, tissues and/or scales.