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Modifiable life style factors and risk for incident endometriosis
Author(s) -
Hemmert Rachael,
Schliep Karen C.,
Willis Sydney,
Peterson Charles Matthew,
Louis Germaine Buck,
AllenBrady Kristina,
Simonsen Sara E.,
Stanford Joseph B.,
Byun Jiyoung,
Smith Ken R.
Publication year - 2019
Publication title -
paediatric and perinatal epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 88
eISSN - 1365-3016
pISSN - 0269-5022
DOI - 10.1111/ppe.12516
Subject(s) - medicine , endometriosis , menarche , menopause , body mass index , cotinine , obstetrics , gynecology , nicotine
Background Caffeine, alcohol, smoking and physical activity are known to alter sex steroid synthesis, which may affect hormone‐dependent gynaecologic disease risk, such as endometriosis; however, few studies have assessed life style factors prior to endometriosis diagnosis. Methods Four hundred and seventy three women, ages 18‐44 years, underwent laparoscopy or laparotomy, regardless of clinical indication, at 14 clinic sites, 2007‐2009. Women with prior surgically confirmed endometriosis were excluded. Life style factors were assessed prior to surgery. Adjusted risk ratios ( RR ) of endometriosis by caffeine, alcohol, smoking (serum cotinine), and physical activity were estimated, adjusting for age, marital status, education, race/ethnicity, age at menarche, gravidity, BMI , study site, and other life style factors. Results There were no associations between women with endometriosis and alcohol consumption ( RR 0.9, 95% CI 0.7, 1.3), caffeine consumption ( RR 1.1, 95% CI 0.8, 1.5), or smoking (serum cotinine <10 vs ≥10 ng/ mL ; RR 1.0, 95% CI 0.7, 1.6). Similar null findings were found between endometriosis and weekly occurrences of physical activity and total walking, moderate, and vigorous activity; a modest trend was found between total daily sitting time and increased endometriosis risk. Conclusions This study, which is unique in its capture of life style exposures prior to incident endometriosis diagnosis, largely found no association between alcohol, caffeine, smoking, and physical activity and risk of endometriosis.