Premium
Parental Body Mass Index, Gestational Weight Gain, and Risk of Macrosomia: a Population‐Based Case–Control Study in C hina
Author(s) -
Yang Shaoping,
Zhou Aifen,
Xiong Chao,
Yang Rong,
Bassig Bryan A.,
Hu Ronghua,
Zhang Yiming,
Yao Cong,
Zhang Yaqi,
Qiu Lin,
Qian Zhengmin,
Trevathan Edwin,
Flick Louise,
Xu Shunqing,
Wang Youjie,
Xia Wei,
Zheng Tongzhang,
Zhang Bin
Publication year - 2015
Publication title -
paediatric and perinatal epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 88
eISSN - 1365-3016
pISSN - 0269-5022
DOI - 10.1111/ppe.12213
Subject(s) - medicine , underweight , overweight , pregnancy , body mass index , obstetrics , fetal macrosomia , weight gain , odds ratio , birth weight , population , obesity , gestational diabetes , gestation , body weight , environmental health , biology , genetics
Background The prevalence of macrosomia has risen markedly worldwide, including in C hina, during the past two decades. Few epidemiological studies, however, have investigated the risk factors for macrosomia in C hina. This study was designed to investigate the associations between parental anthropometric characteristics, gestational weight gain ( GWG ), and risk of macrosomia in C hina. Methods This population‐based, case–control study in W uhan, C hina, included a total of 6341 subjects (870 cases and 5471 controls). Multivariable logistic regression was conducted to calculate odds ratios ( OR ) and 95% confidence intervals ( CI ). Results Mothers or fathers who were overweight or obese before pregnancy had an elevated risk of giving birth to a macrosomic infant compared with their normal weight counterparts. Women with GWG above the Institute of Medicine ( IOM ) recommendation had an adjusted OR of 6.09 [95% CI 5.04, 7.35] for delivering a macrosomic infant compared with women who had GWG within the IOM recommendation. When stratified by maternal pre‐pregnancy body mass index ( BMI ), women who were underweight or normal weight before pregnancy were observed to have a higher risk of macrosomia birth associated with greater GWG . Conclusions Parental pre‐pregnancy overweight/obesity and excessive GWG during pregnancy were highly associated with macrosomia. The association with GWG was most pronounced in mothers who had a normal or underweight pre‐pregnancy BMI . Weight control efforts before pregnancy for mothers and fathers as well as control of maternal gain during pregnancy may reduce the risk of macrosomia.