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Maternal Birthweight Is Associated with Subsequent Risk of Vitamin D Deficiency in Early Pregnancy
Author(s) -
Huang Jonathan Y.,
Qiu Chunfang,
Miller Raymond S.,
Siscovick David S.,
Williams Michelle A.,
Enquobahrie Daniel A.
Publication year - 2013
Publication title -
paediatric and perinatal epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 88
eISSN - 1365-3016
pISSN - 0269-5022
DOI - 10.1111/ppe.12069
Subject(s) - medicine , pregnancy , obstetrics , vitamin d deficiency , overweight , odds ratio , body mass index , vitamin d and neurology , gestational diabetes , confidence interval , gestation , birth weight , endocrinology , genetics , biology
Background Maternal low birthweight and vitamin D deficiency in pregnancy are associated with a similar spectrum of adverse pregnancy outcomes including pre‐eclampsia and gestational diabetes. However, the relationship between maternal birthweight and subsequent vitamin D concentrations in early pregnancy is largely unknown. Methods We assessed whether self‐reported maternal birthweight was associated with risk of early pregnancy vitamin D deficiency (≤20 ng/m L ) among a pregnancy cohort ( n = 658). Serum 25‐hydroxyvitamin D [25( OH ) D ] was measured using liquid chromatography‐tandem mass spectroscopy. Results Adjusting for maternal characteristics and month of blood draw, a 100‐g higher maternal birthweight was associated with a 5.7% decreased risk of early pregnancy 25( OH ) D deficiency [odds ratio ( OR ) = 0.94; 95% confidence interval ( CI ) 0.90, 0.99]. Low‐birthweight (<2500 g) women were 3.7 times as likely to have early pregnancy 25( OH )D deficiency compared with normal‐birthweight women [ OR = 3.69; 95% CI 1.63, 8.34]. These relationships were not modified by either pre‐pregnancy overweight status [body mass index ( BMI ) ≥25 kg/m 2 ] or adulthood weight trajectory ( BMI change ≥2 kg/m 2 from age 18 to pre‐pregnancy). Conclusions Further research on shared developmental mechanisms that determine birthweight and vitamin D homeostasis may help identify targets and related preventative measures for adverse pregnancy and birth outcomes.